• Christopher Columbus as Peter Griffin
  • Gabriel Sanchez as Chris Griffin
  • Queen Isabella I as Lois Griffin
  • Ferdinand Columbus as Dr. Hartman
  • Beatriz Enriquez de Arana as Meg Griffin
  • Antonion de Marchena as Bruce
  • Adrian de Moxica as Tom Tucker
  • Martin Alonso Pinzon as Joe Swanson
  • Captain Mendez as Mayor Adam West

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