- Christopher Columbus as Fry
- Gabriel Sanchez as Hermes
- Queen Isabella I as Leela
- Ferdinand Columbus as Cubert
- Beatriz Enriquez de Arana as Amy
- Antonion de Marchena as George Takei
- Adrian de Moxica as Calculon
- Martin Alonso Pinzon as Dr. Zoidberg
- Captain Mendez as Mayor Poopenmeyer
- Luis de Santangel as Dwight
- Francisco de Bobadilla as Nibbler
- De Arojaz as Kif Kroker
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