- Christopher Columbus as Homer Simpson
- Gabriel Sanchez as Bart Simpson
- Queen Isabella I as Marge Simpson
- Ferdinand Columbus as Waylon Smithers, Jr.
- Beatriz Enriquez de Arana as Lisa Simpson
- Antonion de Marchena as Dr. Julius Hibbert
- Adrian de Moxica as Kent Brockman
- Martin Alonso Pinzon as Principal Seymour Skinner
- Captain Mendez as Mayor Joe Quimby
- Francisco de Bobadilla as Hans Moleman
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