- John Adams as Kermit the Frog
- Benjamin Franklin as Gonzo the Great
- Thomas Jefferson as Dr. Teeth
- John Dickinson as Rizzo the Rat
- Edward Rutledge as Beaker
- John Hancock as Dr. Bunsen Honeydew
- Stephen Hopkins as Fozzie Bear
- Martha Jefferson as Miss Piggy
- Abigail Adams as Annie Sue Pig
- Richard Henry Lee as Jim Henson
- Thomas McKean as Animal
- Caesar Rodney as Sam the Eagle
- and more
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