• Tommy as Arthur
  • Meg (from Family Guy) as DW
  • Dad as Arthur's Dad
  • Mom as Arthur's Mom
  • Spike as Pal
  • Grandpa Dave as Grandpa Lou
  • Grandma Thora as Grandma Lulu
  • Dil as Brain
  • Chuckie as Buster
  • Chaz as Binky
  • Phil as George
  • Lil as Sue Ellen
  • Kimi as Prunella
  • Angelica as Francine
  • Susie as Muffy
  • Mayor Adam West (from Family Guy) as Mr. Ratburn
  • Kira as Mrs. Deegan
  • Drew as Oliver Fresnky
  • Charlotte as Laverne Frensky
  • Lrr (from Futurama) as Toby
  • Mr. Burns (from The Simpsons) as Slink
  • Plankton (from Spongebob) as Rattles

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