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- Tiger as Tom (Tiger and Tom are both cats)
- Fievel Mousekewitz as Jerry (Fievel Mousekewitz and Jerry are both mices)
- Yasha Mousekewitz as Nibbles (Yasha Mousekewitz and Nibbles are both the smallest mices)
- Wylie Burp as Spike (Wylie Burp and Spike are both dogs)