- Yakko as Gru
- Brain as Vector
- Wakko as Tim
- Skippy Squirrel as Dave
- Pinky as Stuart
- Furrball, Dizzy Devil, Li'l Sneezer, Arnold the Pit Bull, Fowlmouth, Bookworm, Concord Condor and Barky Marky (from Tiny Toon Adventures) and The Kid Chorus (from Histeria!) as Minions
- Rita as Margo
- Babs Bunny (from Tiny Toon Adventures) as Edith
- Mindy as Agnes
- Dr. Otto as Dr. Neferio
- Slappy Squirrel as Miss Hattile
- Thaddeus Plotz as Mr. Perkins
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