• Dot Warner as Riley
  • Marita Hippo as Riley's Mom
  • Flavio Hippo as Riley's Dad
  • Wakko Warner as Riley's Boyfriend
  • Minerva Mink as Joy
  • The Brain as Anger
  • Hello Nurse as Disgust
  • Dr. Otto Scratchnsniff as Fear
  • Rita as Sadness
  • Slappy Squirrel as Brain Cancer

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