- DEA Agent Tom Hardy as Homer Simpson
- Captain Julia Osborne as Marge Simpson
- Master Sergeant Nathan West as Ned Flanders
- Colonel Bill Styles as Bart Simpson
- Second Lieutenant Levi Kendall as Principal Seymour Skinner
- Sergrent Ray Dunbar as Waylon Smithers, Jr.
- Jay Pike as Moe Syzlak
- Sergeant Mueller as Dr. Julius Hibbert
- Castro as Barney Gumble
- Nunez as Lisa Simpson
- Dr. Peter Vilmer as Mayor Joe Quimby
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