- Grover as Luigi
- Big Bird as Yoshi
- Elmo as Mario
- Quarantiners as Bowser's Minions
- Aloysius Snuffleupagus as Toad
- Bert as Diddy Kong
- Ernie as Donkey Kong
- Count von Count as Wario
- Cookie Monster as Bowser
- (Yoshi is walking down the street, holding his stomach and looking pale.)
- Yoshi: Oh... I feel like I'm gonna blow chunks of food!
- (Yoshi vomits all over the steps, then collapses. Mario appears.)
- Mario: Oh no, Yoshi has the dinosaur flu!
- (Quarantiners rush over to Yoshi. Luigi now appears.)
- Luigi: The Word of the Day is Quarantine. Q-U-A-R-A-N-T-I-N-E. Quarantine.
- (In the hospital, Yoshi is lying in bed. Doctors are examining him.)
- Yoshi: Toad... is that you?
- Goomba: Oh, he must be hallucinating.
- Toad: Hi, Yoshi. I'm so sorry you're sick.
- Yoshi: I'm scared, Toad. Thank God you can't get it since you're not real.
- (Yoshi then dies.)
- Toad: Yeah, thank G-.
- (Toad dies, then disappears.)
- Wario: (handing out vaccines to everyone) One vaccine, a-hah-hah! Two vaccines, a-hah-hah!
- (Bowser eats the vaccine Wario gives to him)
- [The show cuts to a separate bit]
- Kids: One of these kids is not like the others. One of these kids is dead!
- Announcer: Today's episode brought to you by the letter C.D.C.
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