- Grover as Winnie the Pooh
- Gopher, Lois (from Family Guy), Christopher Robin, Emma (from The Wiggles), Darby and Rabbit as Quarantiners
- Aloysius Snuffleupagus as Roo
- Count von Count as Sulley (from Monsters, Inc.)
- Cookie Monster as Barney (from Barney)
- (Tigger is walking down the street, holding his stomach and looking pale.)
- Tigger: Oh... I feel like I'm gonna blow chunks of food!
- (Tigger vomits all over the steps, then collapses. Piglet appears.)
- Piglet: Oh no, Tigger has the tiger flu!
- (Quarantiners rush over to Tigger. Pooh now appears.)
- Winnie the Pooh: The Word of the Day is Quarantine. Q-U-A-R-A-N-T-I-N-E. Quarantine.
- (In the hospital, Tigger is lying in bed. Doctors are examining him.)
- Tigger: Roo... is that you?
- Emma: Oh, he must be hallucinating.
- Roo: Hi, Tigger. I'm so sorry you're sick.
- Tigger: I'm scared, Roo. Thank God you can't get it since you're not real.
- (Tigger then dies.)
- Roo: Yeah, thank G-.
- (Roo dies, then disappears.)
- Sulley: (handing out vaccines to everyone) One vaccine, a-hah-hah! Two vaccines, a-hah-hah!
- (Barney eats the vaccine Sulley gives to him)
- [The show cuts to a separate bit]
- Kids: One of these kids is not like the others. One of these kids is dead!
- Announcer: Today's episode brought to you by the letter C.D.C.
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