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- Tyrese Gibson as Manny
- Steve as Sid (Steve and Sid both have their names starting with 'S')
- Mailbox as Diego
- Slippery Soap as Scrat
- Scamp (from Lady & The Tramp 2) as The Baby
- Mrs. Pepper as Ellie
- Mr. Nosey and Mr. Small (from The Mr. Men Show) as Crash and Eddie
- Tamera Mowry as Scratte
- Mr. Salt as Buck