- Frog Naveen (from The Princess and the Frog) as Emmet
- Tyrese Gibson as Batman
- Frog Tiana (from The Princess and the Frog) as Wyldstyle/Lucy
- Slippery Soap as Benny
- Toni Braxton as Wonder Woman
- Joe as Metal Beard
- Mailbox as Han Solo
- Gloria Estefan as Uni-Kitty
- Tickety Tock as Mermaid
- Mr. Salt as Vitruvius
- They Might Be Giants as Bad Cop, Lord Busniess/President Business, Superman and Green Lantern
- Tamera Mowry as Ms. Scrathen
- Shovel as Finn
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