• Charlie Chan as Ash Ketchum
  • Yvonne Roland as Misty
  • Betty Adams as May
  • Richard Masters as Brock
  • Lee Chan as Pikachu
  • Arthur Hughes as Cilan
  • Mr. Cartwright as Professor Birch
  • Charlie Chan, Jr. as Harley
  • Mr. Hopkins as Tracey
  • Honorable Charles Zaraka as Gary Oak
  • Inspector Strasser as Buizel
  • Dr. Burton as Max

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