- Charlie Chan as Homer Simpson
- Yvonne Roland as Marge Simpson
- Betty Adams as Lisa Simpson
- Richard Masters as Ned Flanders
- Lee Chan as Bart Simpson
- Arthur Hughes as Barney Gumble
- Mr. Cartwright as Mayor Joe Quimby
- Charlie Chan, Jr. as Waylon Smithers, Jr.
- Mr. Hopkins as Grandpa Abe Simpson
- Honorable Charles Zaraka as Moe Syzlak
- Inspector Strasser as Principal Seymour Skinner
- Dr. Burton as Dr. Julius Hibbert
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