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Chemotherapy

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Chemotherapy drugs used for DSRCT:

Alkaloids

1. Vincristine (Oncovin)

  • Belongs to class of drugs known as vinca alkaloids.
  • It slows or stops the growth of cancer cells in the body.
  • Side effects from vincristine are common and include:
nausea and vomiting
stomach pain and cramps
constipation
diarrhea
jaw pain, headache, or other aches
thinned or brittle hair

2. Vinblastine (Velban)

  • Belongs to class of drugs known as vinca alkaloids.
  • It slows or stops the growth of cancer cells in the body.

Alkylating Agents

1. Cyclophosphamide (Cytoxan)

  • In a class of drugs known as alkylating agents.
  • It slows or stops the growth of cancer cells the body.
  • Side effects from cyclophosphamide are common and include:
thinned or brittle hair
darkened and thickened skin
blistering skin or acne
loss of appetite or weight

2. Ifosfamide (ifex)

  • In a class of drugs known as alkylating agents.
  • It slows or stops the growth of cancer cells in the body.
  • Side effects from ifosfamide are common and include:
thinned or brittle hair
darkened and thickened skin

3. Carboplatin (Paraplatin)

  • Belongs to the group of medicines known as alkylating agents.

4. Melphalan (Alkeran)

  • Belongs to the group of medicines called alkylating agents. It slows or stops the growth of cancer cells.
  • Used in high doses during stem cell rescue.

5. Cisplatin (Platinol)

  • It slows or stops the growth of cancer cells.
  • Belongs to the group of medicines known as alkylating agents.
  • Interferes with the growth of cancer cells, which are eventually destroyed.
  • Treats bladder, ovaries, and testicle cancers.

6. Thiotepa (Thioplex)

  • In a class of drugs known as alkylating agents. It slows or stops the growth of cancer cells in the body.
  • Used in high doses during stem cell rescue.

7. Darcarbazine (DTIC Dome, DIC)

  • Belongs to the group of medicines known as alkylating agents.
  • Interferes with the growth of cancer cells, which are eventually destroyed.
  • treats melanoma, soft tissue sarcoma, neuroblastoma, hodgkin's disease, ewing's sarcoma.

Angiogenesis Inhibitor

1. Thalidomide (Thalidomid)

  • Works as a angiogenesis inhibitor against cancer cells.
  • Cancers need to produce a network of new blood vessels in order to grow.
  • Thalidomide can stop cancers from developing new blood vessels.

Antibiotics

1. Doxorubicin (Adriamycin)

  • A type of antibiotic that is only used in cancer chemotherapy.
  • It slows or stops the growth of cancer cells.
  • Doxorubicin is one of the chemicals that can be heated and effectively used in hyperthermic chemoperfusion.
  • Side effects from doxorubicin are common and include:
nausea and vomiting which may last up to 24-48 hours after treatment
loss of appetite
diarrhea
difficulty swallowing
thinned or brittle hair
skin irritation (sunburn-like) or rash on areas previously exposed to radiation treatments
darkening of fingernails or toenails
swelling, pain, redness, or peeling of skin on the palms and soles of the feet

2. Dactinomycin (Actinomycin-D)

  • A type of antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells.

3. Bleomycin (Blenoxane)

  • An antibiotic that is used only for its cancer-fighting effects; it slows or stops the growth of cancer cells in the body.
  • Used to treat AIDS, renal carcinoma, lymphomas, testicular carcinomas, malignant pleural effusions,

4. Mitomycin C (Mutamycin)

  • An antibiotic that is used for its cancer fighting effects to slow or stop the growth of cancer cells.
  • Mitomycin C is one of the chemicals that can be heated and effectively used in hyperthermic chemoperfusion.

Antineoplastics

1. Irinotecan (Camptosar)

  • Belongs to the group of medicines called antineoplastics.
  • Interferes with the growth of cancer cells, which are eventually destroyed.
  • May be used in hyperthermic chemoperfusion.

2. Topotecan (Hycamtin)

  • Belongs to the group of medicines known as antineoplastics.
  • Interferes with the growth of cancer cells, which are eventually destroyed.

3. Temozolomide (Temodar)

  • Belongs to the general group of medicines known as antineoplastics.
  • Seems to interfere with the growth of cancer cells, which are then eventually destroyed by the body.

4. Epirubicin (Ellence)

  • Belongs to the general group of medicines known as antineoplastics.
  • Interferes with the growth of cancer cells, which are then eventually destroyed by the body.

5. Vinblastine (Velban)

  • Belongs to the group of medicines known as antineoplastic agents.
  • Interferes with the growth of cancer cells, which are eventually destroyed.

6. Vinorelbine (Navelbine)

  • Belongs to the general group of medicines known as antineoplastics.
  • Interferes with the growth of cancer cells, which are eventually destroyed.

7. Docetaxel (Taxotere)

  • Belongs to the group of medicines called antineoplastics.
  • Interferes with the growth of cancer cells, which are eventually destroyed.

Antimetabolites

1. Gemcitabine (Gemzar)

  • Belongs to the group of medicines called antimetabolites.
  • Interferes with the growth of cancer cells, which are eventually destroyed.

2. Fludarabine (Fludara)

  • Group of medicines called antimetabolites.
  • Interferes with the growth of cancer cells, which are eventually destroyed
  • Used in high doses during stem cell rescue.

COX-2 Inhibitors

1. Celecoxib (Celebrex)

  • In a class of NSAIDs called COX-2 inhibitors.
  • Has been used to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum.
  • Currently under warning by FDA for risk of heart attack or stroke.

Podophyllotoxin Derivatives

1. Etoposide (VP-16)

  • In a class of drugs known as podophyllotoxin derivatives. **It slows or stops the growth of cancer cells in the body.
  • Side effects from etoposide are common and include:
nausea and vomiting
loss of appetite
constipation
diarrhea
stomach pain
changes in taste
thinned or brittle hair

Spindle Poison/Mitotic Inhibitor

1. Gemcitabine and Docetaxel in Metastatic Sarcoma: Past, Present, and Future

Used to Protect Organs

1. Dexrazoxane (Zinecard)


2. Mesna (Mesnex)

3. Darbepoetin alfa (Aranesp)

Complementary Drugs

Prednisone (Deltasone)

Dexamethasone (Decadron)

Warfarin - Used to prevent blood clots from forming or growing larger.

Zofran - Used to prevent nausea and vomiting that may occur during therapy.

Kytril - Used to prevent nausea and vomiting that may occur during treatment.

Lorazepam (Ativan) - Used to relieve anxiety.

Heparin - Blood thinner used to prevent the blood from clotting.

Famotidine (Pepcid) - Used during chemotherapy treatments to reduce acid reflux, nausea, and vomiting.

Chemotherapy Acronyms

List of acronyms commonly used for certain drug protocols during treatments.

BIC= Bleomycin, Ifosfamide, Carboplatin, Mesna

CAP = Cyclophosphamide (Cytoxan), Doxorubicin (Adriamycin), Cisplatin

DTIC = Darcarbazine

EPOCH = Etoposide, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin (Adriamycin),

ICE = Ifosfamide, Carboplatin, Etoposide

IE = Ifosfamide, Etoposide

IFoVP = Ifosfamide, Etoposide, Mesna

PAVEP = Cyclophosphamide (Cytoxan), Etoposide, Doxorubicin (Adriamycin), and Cisplatin

PEVEP = Cyclophosphamide (Cytoxan), Etoposide, Epirubicin, and Cisplatin

Topo/CTX =Topotecan, Cyclophosphamide (Cytoxan), Filgrastim

VAC = Vincristine, Dactinomycin, Cyclophosphamide (Cytoxan)

VAC/Adr = Vincristine, Doxorubicin, Cyclophosphamide (Cytoxan), Dactinomycin

VI = Vincristine and Irinotecan

DSRCT References

Contact: dsrct.wiki@gmail.com

'Disclaimer: This site is for informational and idea exchange among patients only. We are not doctors and do not offer medical advice. Please check with your own physician if you have any unusual symptoms or questions concerning treatment.'

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