- Numbuh 2 as Manny Rivera/El Tigre
- Numbuh 5 as Frida Suarez
- Numbuh 4 as White Pantera
- Numbuh 3 as Maria Rivera
- Numbuh 1 as Puma Loco
- Lizzie as Sartana of the Dead
- King Sandy as Sergio/Senor Sinistro
- Chad as Dr. Chipotle Jr.
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