- Officer Danny "Pac-Man" McGavin as Homer Simpson
- Officer Bob Hodges as Bart Simpson
- Louisa Gomez as Marge Simpson
- Ron Delaney as Ned Flanders
- Clarence "High Top" Brown as Moe Syzlak
- Leo "Frog" Lopez as Principal Seymour Skinner
- Larry "Looney Tunes" Sylvester as Barney Gumble
- Rocket as Dr. Julius Hibbert
- T-Bone as Kent Brockman
- Killer Bee as John
- Felipe as Chief Clancy Wiggum
- Bird as Sideshow Mel
- 21st Street Gang Member as Waylon Smithers, Jr.
- Locita as Allison Taylor
- and more
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