- Frank Heffley as Horton
- Greg Heffley as the Mayor of Who-ville
- Rodrick Heffley as Morton
- Holly Hills as Sally
- Patty Farrell as Kangaa
- Chip (from Beauty and the Beast) as Kangaa's son
- Megara (from Hercules) as Katie
- Rowley Jefferson as Jojo
- Mr. Gerabit as Vlad
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