• Frank Heffley as Horton
  • Greg Heffley as the Mayor of Who-ville
  • Rodrick Heffley as Morton
  • Holly Hills as Sally
  • Patty Farrell as Kangaa
  • Chip (from Beauty and the Beast) as Kangaa's son
  • Megara (from Hercules) as Katie
  • Rowley Jefferson as Jojo
  • Mr. Gerabit as Vlad

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