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Cast in August 2010.
- Mater (from Cars) as Richard 'Rick' O'Connell
- Marie (from The Aristocats) as Evelyn Carnahan
- Rabbit (from Winnie the Pooh) as Jonathan Carnahan
- Woody (from Toy Story) as High Priest Imhotep
- Wall-E (from Wall-E) as Beni Gabor
- Simba (from The Lion King) as Ardeth Bay
- Mr. Smee (from Peter Pan) as Dr. Allen Chamberlain
- Tramp (from Lady and the Tramp) as Dr. Terrence Bay
- Zack (from The Suite Life of Zack & Cody) as Captain Winston Havlock