- Doc Holiday as Homer Simpson
- Kate Elder as Lisa Simpson
- Wyatt Earp as Bart Simpson
- Ike Clanton as Ned Flanders
- The Kid as Barney Gumble
- Clum as Mayor Joe Quimby
- Bartlett as Dr. Julius Hibbert
- Tombstone Sheriff John Behan as Principal Seymour Skinner
- Virgil Earp as Waylon Smithers, Jr.
- James Earp as Grandpa Abe Simpson
- Mattie Earp as Marge Simpson
- Alley Earp as Allison Taylor
- Frank McLowery as Moe Syzlak
- Concha as Maggie Simpson
- Morgan Earp as Kent Brockman
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