He voiced Scooby-Doo on Scooby-Doo, Papa Smurf on The Smurfs, Boo Boo Bear and Ranger Smith on Yogi Bear, Muttley, Gravel Slag, Little Gruesome, Professor Pat Pending, Ring-a-Ding and Sawtooth on Wacky Races, Muttley, Zilly, and Klunk on Dastardly and Muttley, Snoozy, Zippy, Dum-Dum and Pockets on The Perils of Penelope Pitstop, He-Man on the Masters of the Universe Golden Book video, Ratchet, Gears, and Construction Scavenger on Transformers, Louie and Snichey on the Pound Puppies TV special, King Klutzes on Fantastic Max, and Hamton J. Pig on Tiny Toon Adventures.
Messick suffered a second stroke and died on October 24, 1997. He was cremated. His ashes were scattered into the Pacific Ocean at the Point Lobos State Reserve.
A year later in 1998, the film Scooby Doo on Zombie Island was dedicated to his memory.