• Dr. John Dolittle as Mordecai
  • Grandpa Archer Dolittle as Muscle Man
  • Calloway as Benson
  • Rodney the Guinea Pig as Mr. Maellard
  • Dr. Gene "Geno" Reiss as Rigby
  • Lisa Dolittle as Margaret
  • Maya Dolittle as Eileen
  • Charisse Dolittle as Starla
  • Possum as Evil Taxi
  • Siberian Husky as Iacedrom
  • and more

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