• Dr. John Dolittle as The Cat in the Hat
  • Charisse Dolittle as Cindy Lou Who
  • Joe Potter as Mack the Turtle
  • Riley as Sam-I-Am
  • Lisa Dolittle as Pam-I-Am
  • Maya Dolittle as Sarah Hall-Small
  • Eric as Mr. Brown
  • Logger as Norval the Fish
  • Archie as The Lorax
  • Ava as Annie DeLoo
  • Drunk Monkey as Joey
  • Lucky Dolittle as King Derwin
  • Alligator as Thidwick the Big-Hearted Moose
  • Giraffe as Sylvester McMonkey McBean
  • and more

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