- The Cat in the Hat as Miles Monroe
- Pam-I-Am as Luna Schlosser
- The Grinch as Dr. Nero
- Cindy Lou Who as Ellen Pogrebin
- King Derwin as Dr. Melik
- Vlad Vladikoff as Dr. Tyson
- Mr. Brown as Dr. Dean
- The Lorax as D. Aragon
- Sarah Hall-Small as Dr. Orva
- Norval the Fish as Rainer Krebs
- Little Cat B as Herald Cohen
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