- US Marshal John Kruger as Homer Simpson
- US Marshal Robert DeGuerin as Mr. Burns
- Lee Cullen as Marge Simpson
- WITSEC Chief Arthur Beller as Bart Simpson
- Johnny Casteleone as Moe Syzlak
- William Donohue as Waylon Smithers, Jr.
- WITSEC Deptuty Monroe as Principal Seymour Skinner
- Daniel Harper as Ned Flanders
- Tony Two-Toes as Ralph Wiggum
- Sergei Ivanovich Petrovsky as Grandpa Abe Simpson
- Morehart as Mayor Joe Quimby
- Agent Calderon as Chief Clancy Wiggum
- Agent Schiff as Lenny
- Agent Dutton as Carl
- Agent Corman as Milhouse Van Houten
- Claire Isaacs as Lisa Simpson
- and more
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