- 'Chris (from Family Guy) as Alex
- Homer Simpson (from The Simpsons) as Tuck Simms
- Horton (from Horton Hears a Who) as Munch
- Human Torch as Dr. Lawrence Masden
- Joe (from Family Guy) as Calvin
- Bernie the Gorilla (from Zookeeper) as Pawn Shop Owner
- Dr. Doom as Joey
- Invisible Woman as Tuck's Mom
- Thing as Emma's Dad
- Mr. Fantastic as Blake
- Meg (from Family Guy) as Emma's Mom
- Gabato (from Journey 2: The Mysterious Island) as Security Guard
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