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Garfield/What A Mess is a parody featuring video clips from Garfield and Friends and audio clips from What A Mess
- Booker as What A Mess
- Baby Turtle as Baldwin
- The Weasel as Trash
- Bo as Frank
- Wade as Norton
- Chloe as Felicia
- Arlene as Duchess
- Roy as Dad
- Mrs. Chicken as Mom
- Orson as Son
- Lanolin as Daughter
- Odie as Bernie
- Amy Rose (from Sonic) as Trixie
- The Fox as Mr. DeSade
- The Wolf as Guard Dog
- The Salesman Fox as Buzz Sr.
- Rufus T. Crab the Dog as Buzz Jr.
- Worms as Tiny Aliens
- Wart and Mort as Trash's Friends
- Gort as Freddie the Rat
- Aloysius as Museum Manager
- Penelope as Poppet
- Mrs. Pig (Aloysius's Mom) as Mail Carrier
- Betty Buddy Bear as Ramona
- Madman Murray as Trash's Owner
- Bobby Buddy Bear as Kid in Museum