• Peter Venkman as Ash Ketchum
  • Raymond Stantz as Pikachu
  • Dana Barrett as Zoey
  • Baby Oscar as Drew
  • Egon Spengler as Professor Birch
  • Louis Tully as Max
  • Winston Zeddmore as Gary Oak
  • Janine Melnitz as Misty
  • Dr. Janosz Poha as Cilan
  • Judge Stephen Wexler as Harley
  • Prosecuting Attorney "Kitten" as May
  • Mayor "Lenny" as Tracey
  • Vigo the Carpathian as Mewtwo

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