Fierstein was born in Brooklyn, New York, the song of Jacqueline Harriet, a School Librarian and Irving Fierstein, a Handkerchief Manufacturer. Raised Jewish, Fierstein is no an Atheist.
Fierstein occasionally writes columns about gay issuse. He was openly gay at a time when very few celebrities were. His careers as a Stand-up Comic and Female Impersonator are mostly behind him. Fierstein resides in Ridgefield, Connecticut.
- The Demon Murder Case (1983, voice) - Demon
- The Times of Harvey Milk (1984) - Narrator
- The Simpsons (1990, two Episodes "Simpson and Delilah" and "Three Gays of the Condo") - Karl
- Madeline (1993, TV series) - Various Characters
- Babe and Emily (1995, voice) -
- Happily Ever After: Fairy Tales for Every Child (1997, one Episode "Thumbelina") - Mrs. Leaperman
- Stories from My Childhood (1998, one Episode "Alice and the Mystery of the Third Planet") - Grambo
- Babe and Emily: Pig and Girl in the City (1998, voice) -
- Mulan (1998, voice) - Yao
- Mulan Story Studio (1998, Video Game) - Yao
- X-Chromosome (1999, TV series) - Mom/Little Mom Head
- The Sissy Duckling (1999, voice) - Elmer
- Madeline: Lost in Paris (1999, voice) -
- Digimon: The Movie (2000, voice) - Electra