- Sean Mercer as Peter Griffin
- Kurt Muller as Chris Griffin
- Anna Maria D'Alessandro as Lois Griffin
- "Pockets" as Derek Wilcox
- Charles Maurey as Brian Griffin
- Little Wolf as Jesus
- Brande De La Court as Dr. Hartman
- Luis Francisco Garcia Lopez as Cleveland Brown
- Dr. Sanderson as Mayor Adam West
- Nurse as Jillian
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