• Jerusha Hale as Lisa Simpson
  • Reverend Abner Hale as Bart Simpson
  • Queen Malama Kanakoa as Marge Simpson
  • Dr. John Whipple as Homer Simpson
  • Capt. Rafer Hoxworth as Grandpa Abe Simpson
  • Charles Bromley as Otto
  • Prince Keoki as Krusty the Clown
  • Noelani as Edna Krabappel
  • Rev. Immanuel Quigley as Ralph Wiggum
  • Rev. Dr. Thorn as Chief Clancy Wiggum
  • Gideon Hale as Mr. Burns
  • Bette Middler as Patty Bouvier also had her first on-screen movie appearance in Hawaii as a ship passenger with no dialogue.

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