- Jerusha Hale as Lisa Simpson
- Reverend Abner Hale as Bart Simpson
- Queen Malama Kanakoa as Marge Simpson
- Dr. John Whipple as Homer Simpson
- Capt. Rafer Hoxworth as Grandpa Abe Simpson
- Charles Bromley as Otto
- Prince Keoki as Krusty the Clown
- Noelani as Edna Krabappel
- Rev. Immanuel Quigley as Ralph Wiggum
- Rev. Dr. Thorn as Chief Clancy Wiggum
- Gideon Hale as Mr. Burns
- Bette Middler as Patty Bouvier also had her first on-screen movie appearance in Hawaii as a ship passenger with no dialogue.
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