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In Memory

Smsunfl Marlena

Patient Information

Age: 24

Sex: Female

Diagnosed: 1/05

Location: Virginia

Diagnosis: Stage III DSRCT

Hospital:

Oncologist

No evidence of disease: 5/4/05

Relapse: 6/17/05

No evidence of disease: 1/17/06

Relapse: 12/13/06 - Lesions to the brain

Passed away: 7/27/07

Caringbridge Journal

Back

Treatment

Surgery

Debulking surgery with 90 minute heated chemo bath (Intraperitoneal hyperthermic chemoperfusion) done by Dr Paul Sugarbaker.
Received a hysterectomy, splenectomy, greater omentectomy, a right colectomy, numerous lymph nodes in the abdomen were removed, gallbladder removed, diaphram was scraped, and tumor was removed from liver.

Chemotherapy

  • First Line:
Carboplatinum and Gemzar
Daily Gleevec pills
  • Second Line:
Ifosfamide and Etoposide
Vincristine, Doxorubicin, and Mesna

Stem Cell Rescue

Fludarabine and Melphalan high dose chemo
Allogeneic stem cell transplant. Received brothers stem cells.
Granulocyte donor (white blood donor) - husband matches.
Takes approximately 14 days for the new bone marrow to engraft


Radiation

18 different Fields (most people have only 2-4 Fields) and one treatment takes an hour. It stops 18 times for over 30 different “shots” of radiation that last about 15 seconds each. About 2/3 through the process have to be lined back up so they can do pelvic region. 4 weeks in the abdomen/pelvic area and 7 weeks on neck region (lympth nodes)

Relapse

Cyber Knife

Time Line

Date Test Treatment Chemicals Result
1/5/05 0 0 0 Diagnosed. CA-125 marker was 1030. (normal is 30)
2/8/05 0 Debulking surgery and intraperitoneal hyperthermic chemoperfusion. 0 5 1/2 weeks in the hospital to recover from surgery.
2/12/05 0 Chemotherapy Carboplatinum and Gemzar 1 0
3/05 CT 0 0 Clear.
3/05 0 Chemotherapy 0 Once a week for three weeks with one week off. Daily Gleevac.
4/05 0 0 0 0
5/4/05 CT 0 0 Clear. No evidence of disease.
5/25/05 0 Chemotherapy Cycle 1 0 0
6/17/05 Exam 0 0 Enlarged lymph nodes in the neck (measured 3.5cm). Relapse.
6/05 CT 0 0 "Shading" or marginal tumor growth in abdominal area, nothing solid.
6/05 0 Chemotherapy Cycle 2 #1 Ifosfamide and Etoposide (given over 4 days) - #2 Vincristine, Doxorubicin, and Mesna (given in 1 day) 0
7/05 CT Chemotherapy Cycle 3 0 Lymph node in neck measures 1.6cm
8/05 0 Chemotherapy Cycle 4 0 0
9/17/05 CT Chemotherapy Cycle 5 0 CT scan revealed significant shrinkage (1.3cm) - no more fluid around the lungs
10/05 0 Chemotherapy Cycle 6 0 Shrinking.
11/05 0 Chemotherapy Cyle 7 0 Dirty Harry still shrinking. :-)
12/05 0 Chemotherapy Cycle 8 0 Dirty Harry gone.
1/17/06 CT Chemotherapy Cycle 9 0 CT scan clear except for 3cm cyst on bladder. No evidence of disease for all lympth nodes.
2/06 0 Chemotherapy Cycle 10 0 0
2/28/06 MRI 0 0 No sign of tumor anywhere except the cyst on bladder and a nodule that may be dead tissue
3/8/06 PET 0 0 Fistula (small pocket of fluid) behind bladder -result from large surgery. The cyst did not light up, it's not cancer. Nodule gone. No evidence of disease.
3/14/06 0 Chemotherapy Cycle 11 0 0
4/6/06 0 Chemotherapy Cycle 12 0 0
5/2/06 0 Minor Surgery to place central line for Stem Cell transplant 0 0
5/3/06 0 High dose chemo to prepare for Stem Cell Fludarabine. Immune Globulin-Gamunex to boost immune system.
5/05/06 0 0 0 Admitted to Bone Marrow Transplant unit to start Stem Cell transplant
5/7/06 0 High dose chemotherapy Melphelan 0
5/9/06 0 Allogeneic stem cell transplant started. Received brothers stem cells. 0 Husband providing granulocytes to boost white blood counts.
6/3/06 0 0 0 Stem Cells grafting. The ymphoyd cells (ones that kill cancer) are 100% brothers. Myelo cells (takes care of bacteria and fungus) are 75% brothers.
6/7/06 0 0 0 Released from hospital.
6/15/06 CT 0 0 Clean. No evidence of disease.
6/30/06 0 Radiation 0 0
7/06 0 Radiation 0 0
8/06 0 Radiation 0 0
9/06 0 0 0 0
10/06 0 0 0 0
11/06 0 0 0 0
11/24/06 Six months study from transplant 0 0 Everything okay
12/1/06 CT 0 0 Some abnormalities spotted on brain and liver
12/11/06 Biopsy on brain 0 0 0
12/13/06 0 0 Relapse 2 large DSRCT lesions, several smaller lesions found on brain (9 in total)
1/07 0 CAM 0 0
2/07 0 CAM 0 0
3/07 CT Consult about using 'cyber knife' 0 Slight growth in brain, 2 new lesions on liver
4/07 0 Gamma Knife used on 9 brain lesions. Chemotherapy. 0 Found a couple lesions on lungs. Chemo stopped for now.
5/07 0 0 0 0
6/07 0 0 0 0
7/27/07 0 0 0 Passed away


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