Huckle and his friends (along with Mac, Bloo, Bill, Aldo, The Powerpuff Girls and their friends) have traveled to London, England and met Pongo, Perdita, and their 15 puppies. They soon learned that the puppies were stolen by Jasper and Horace. They have been hired by the most outrageous Disney villain of all, Cruella De Vil, whom Mojo Jojo, Terrence, and Duchess, work for. Can Huckle, Lowly, Mac, Bloo, Wilt, Eduardo, Coco, Frankie, Mr. Herriman, The Grim Reaper, Wilt, Eduardo, Spreg, Mandy, Mindy, Principal Pixiefrog, Edward, Chip, Skip, Samson, Scoutmaster Lumpus, and Slinkman help Pongo and Perdita get Mac, Bloo,, Coco, Billy, Irwin, Pudin, Adam Lyon, Jake Spidermonkey, Raj, Lazlo, Clam, and the puppies back to London before the villains do any harm on them? You be the judge
Adam Lyon, Jake Spidermonkey, Principal Pixiefrog, Lazlo, Raj, Clam. Scoutmaster Lumpus, Scout Slinkman, Edward, Chip, Skip, Samson, The Grim Reaper, Billy, Mandy, Mandy, Irwin, Pudin, Spreg, Mac, Bloo, Wilt, Eduardo, Coco, Frankie Foster, Bill, Aldo, The Powerpuff Girls, Terrence, Duchess, Berry, Mojo Jojo guest star in the film.
Like in Simba, Timon, and Pumbaa's Adventures of 101 Dalmatians, Pooh's Adventures of 101 Dalmatians, and Yogi Bear's Adventures of 101 Dalmatians, Mac, Bloo, , Coco, Huckle, Lowly, Billy, Irwin, Pudin', Lazlo, Raj, Clam, Adam Lyon and Jake Spidermonkey get kidnapped by Horace and Jasper with Pongo and Perdita's 15 puppies.
My Gym Partner's A Monkey, Camp Lazlo, The Grim Adventures of Billy & Mandy, Foster's Home for Imaginary Friends, Sitting Ducks, and the Powerpuff Girls were all made by Cartoon Network.