- Charlotte Hollis as Misty
- Miriam Deering as May
- Dr. Drew Bayliss as Ash Ketchum
- Velma Cruther as Iris
- Harry Willis as Professor Oak
- Big Sam Hollis as Mewtwo
- Jewel Mayhew as Zoey
- John Mayhew as Max
- Foreman as Drew
- Paul Merchand as Tracey
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