- Inspector Gadget as Homer Simpson
- G2 as Marge Simpson
- Dr. Claw as Mr. Burns
- Penny as Lisa Simpson
- Brain the Dog as Bart Simpson
- Gadgetmobile as Moe Syzlak
- Chief Quimby as Kent Brockman
- Mayor Wilson as Patty Bouvier
- Baxter as Grandpa Abe Simpson
- Brick as Barney Gumble
- Jungle Bob as Sideshow Mel
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