- Johnny Knoxville as Charley
- Bam Margera as Mr. Howard
- Ryan Dunn as Mac
- Chris Pontius as T-Bone
- Steve-O as Speckle the Puppy
- Dave England as Robbie the Panda
- Preston Lacy as Clifford
- Wee-Man as Darnell Duck
- Brandon Novak as Mr. Bleakman (cameo)
- Kat Von D as Emily Elizabeth (cameo)
- Mark Zupan as Charley's Dad (cameo)
- John Waters as The Evil Dog (cameo)
- and more
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