• Johnny Knoxville as Gru
  • Bam Margera as Dr. Nefario
  • Chris Pontius as Dave the Minion
  • Dave England as El Macho
  • Wee-Man as Silas Ramsbottom
  • Ryan Dunn as Stuart the Minion
  • Kat Von D as Edith (cameo)
  • Rip Taylor as Tim the Minion (cameo)
  • Preston Lacy and Steve-O as Evil Minions
  • and more

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