- Johnny Knoxville as Percy Jackson
- Bam Mergera as Luke Castellan
- Ryan Dunn as Grover Underwood
- Chris Pontius as Tyson
- Steve-O as Chiron
- Dave England as Polyp[hemus
- Preston Lacy as Dionysus
- Wee-Man as Chris Rodriguez
- Brandon Novak as Mr. Brunner (cameo)
- Kat Von D as Clarisse La Rue (cameo)
- Mark Zupan as Ethan Nakamura (cameo)
- John Waters as Young Grover Underwood (cameo)
- and more
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