• Sheen Estevez as Bloo
  • Jimmy Neutron as Mac
  • Hugh Neutron as Wilt
  • Socks Morton (from Whatever Happened to Robot Jones?) as Eduardo
  • Libby Folfax as Coco
  • Cindy Vortex as Frankie Foster
  • Principal Willoughby as Mr. Herriman (with Commander Baker as an extra)
  • Mrs. Fowl as Madame Foster
  • Professor Calamitous as Terrence
  • Goddard as Cheese
  • Carl Wheezer as Jackie Khones
  • Beautiful Gorgeous as Duchess
  • Carl's Mom as Mrs. Applebee
  • Carl's Dad as Mr. Applebee
  • Russ Cargill (from The Simpsons Movie) as Millionaire
  • Angelica Pickles (from Rugrats) as Millionaire's Daughter