Joe's Laboratory is a FamilyChoice original animated series that parodies Dexter's Laboratory. It ran from September 7, 2013 until February 27, 2016 and takes place during the events of the Indigo League episode: The School of Hard Knocks.
- Join our genius student from the Pokemon Tech called Joe (from The School of Hard Knocks), as he lives at home with his teenage sister Lara Laramie (from The Flame Pokemon-athon) and his parents Trixie (from Love, Totodile Style) and Dr. Wiseman (from Fowl Play). He has a crush on Emily whose neighbor is Ralph (from Wherefore Art Thou, Pokemon?) and is friends with Chopper (from The Bridge Bike Gang) who has a crush on Ramona (from The Stolen Stones). He also has a fierce encounter with Goneff (from The Wayward Wobbuffet) whose girlfriend is Wendy (from Dues and Don'ts) and has a neighbor in tow named Mikeosu (from Meowth Rules) whose love interest and grandfather are Maya (from Dueling Heroes and The Perfect Match) and Shimajio. There's also Lara's love interest Melvin (from The March of The Exeggutor Squad), Lara's rival Dario (also from The Flame Pokemon-athon) whose love interest is Lorelei Brooks (from Goldfish Warning!), Chopper's sister Katrina (from Lights, Camera, Quack-tion!) whose love interest is Otoshi (from Bad To The Bone) Chopper's neighbor Nario (from Wobbu-Palooza) whose love interest and mother are Charmaine (from The Apple Corp) and Lulu (also from Wobbu-Palooza), and Chopper's rival Tyson (from Talking About An Evolution and Rage of Innocence) whose love interest is Maddy Maddoi (from Mega Man NT: Warrior), plus Ramona's brother Keegan (from The Stolen Stones) whose love interest and rival are Cherry (from The Psychic Sidekicks) and Koji (from Good Quil Hunting) who is Ramona's worst nightmare and has a crush on Jordan Hanson (from Goldfish Warning!).
- Kayzie Rogers as Joe
- Lisa Ortiz as Lara Laramie, Wendy, Charmaine
- Amy Birnbaum as Trixie, Emily, Katrina
- Mike Pollock as Dr. Wiseman, Melvin
- Tara Jayne as Ralph, Keegan
- Matthew Mitler as Chopper
- Roxanne Beck as Ramona
- Sean Schemmel as Goneff
- Nathan Price as Mikeosu
- Amy Palant as Maya
- ??? as Shimajio
- Jimmy Zoppi as Dario, Otoshi
- Kelly Sheridan as Lorelei Brooks
- Andrew Rannells as Nario
- Kayzie Rogers as Lulu
- Dan Green as Tyson
- ??? as Maddy Maddoi
- Kerry Williams as Cherry
- Ted Lewis as Koji
- Bryn McAuley as Jordan Hanson
Season 1 (2013-2014)
Season 2 (2014-2015)
Season 3 (2015-2016)
- This is a parody of Cartoon Network's Dexter's Laboratory.
- Mike Pollock voices Dr. Wiseman and Melvin due to Maddie Blaustein's passing.
- Ramona and Keegan appear together.