Joe's Laboratory is a FamilyChoice series made in 2011.
- It centers on Joe, as he lives his life with his teenage brother Mikeosu, his parents Trixie and Dr. Wiseman, and his grandfather Shimajio. He develops a crush on Emily, who is the neighbor of Ralph and has a good friend in Chopper whose crush is Ramona (who currently lives with her brother Keegan and her parents Naomi and Professor Birch). He is also head to head with his rival Damian who is currently with Marina, and meets many girls like Duplica, Katrina, Krystal, and Ranger Mason (who all live with Todd Snap, Keith, Dorian and Salvador). Joe also encounters Lt. Surge, who is with Sabrina and best friends Blaine and Bruno (who are with Whitney and Lorelei or Prima for some reason). Chopper also has a brother named Nario (who is currently with Charmaine) and also meets his rival Koji, who is Keegan's enemy and Ramona's worst nightmare and currently lives with Igglybuff singer Brittney. There's also Ralph's love interest and Cardcaptors character Nikki, Ralph's best friends Sylvester and Nelson, who are also with Rita and Chelsea, Ralph's main rival Mackenzie, who is currently with his older brother Alex Davis whose love interest is Chigusa, and also has a crush on Dorie Goodwyn. Keegan also has a crush on Cherry and meets Dayton, his new rival whose lover is Mirabelle Haywood. Keegan also makes friends with Malachi and Oliver who are with Reanne Griffith and Polly Ester. There's even Lt. Surge's rival Umberto, who is currently with movie-exclusive character Maren, Lt. Surge's enemies Yas and Kaz, who are the gym leaders of Dark City. Also appearing in it is Mikeosu's love interest Maya. Also among the cast are Alex Davis' friends Falkner, the leader of Violet City and Raiden the sumo champion, whose lovers are Miki and Mariah. Alex Davis also meets his rival Bugsy whose love interest and best friends are Zoe Drake, Morty and Eusine, who currently live with Jasmine and Tierra. There's also Janina and Myron, relatives to Jasmine.
- Kayzie Rogers as Joe, Nelson, Mackenzie, Alex Davis, Oliver
- Nathan Price as Mikeosu
- Amy Birnbaum as Trixie, Emily, Katrina, Sylvester
- Mike Pollock as Dr. Wiseman
- Tara Jayne as Ralph, Keegan, Krystal, Dayton, Malachi, Ranger Mason, Maren
- Matthew Mitler as Chopper
- Roxanne Beck as Ramona, Naomi
- as Peofessor Birch
- Eli James as Damian
- Lisa Ortiz as Marina, Sabrina, Charmaine, Chigusa
- Megan Hollingshead as Duplica, Whitney
- Jimmy Zoppi as Todd Snap
- Ted Lewis as Keith, Blaine, Koji, Yas
- Michael Sinterniklaas as Dorian
- Pete Zarustica as Salvador
- as Lt. Surge
- as Bruno
- Janye Grand as Lorelei
- Andrew Rannells as Nario
- Kerry Williamas as Brittney, Cherry, Janina
- Kelly Sheridan as Nikki
- as Rita
- Jocleyne Loewen as Chelsea
- Amy Palant as Dorie Goodwyn, Maya
- Kether Donahue as Mirabelle Haywood
- Rebecca Soler as Reanne Griffith
- as Polly Ester
- as Umberto
- as Kaz
Season 1 (2011-2012)
Season 2 (2012-2013)
Season 3 (2013-2014)
Season 4 (2014-2015)
Season 5 (2015-2016)
Season 6 (2016-2017)
- The show centering on Joe himself.
- Mikeosu is revealed to have a crush on Whirl Cup lady Maya.
- Lt. Surge and The Vermilion Gang also appear.