- Matt Farrell (from Die Hard 4) as Gru
- Draco Malfoy (from Harry Potter) as Vector
- Hank as Dr. Nefario
- Kailani as Margo
- Liz as Edith
- Hazel (from Dolphin Tale) as Agnes
- Sean as Tim the Minion
- Sawyer (from Dolphin Tale) as Phil the Minion
- T-Rex (from Journey to the Center of the Earth) as Mr. Perkins
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