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- Dr. Rodney Rathbone as Homer Simpson
- Lloyd Garmadon (from Ninjago) as Bart Simpson
- Ann Lee as Marge Simpson
- Angelica Pickles (from Rugrats) as Lisa Simpson
- L'il Pea (from Nuttiest Nutcracker) as Maggie Simpson
- Jack McHammer as Groundkeeper Willie (Jack and Willie are both have red hair and beard)
- Frank Rock as Moe
- Quinton Steele as Grandpa Abe
- Lord Vampyre as Mr. Burns
- The Crazy Scientist as Smithers