- Josephine "Jo" March as May
- Friedrich Bhaer as Ash Ketchum
- Margaret "Meg" March as Misty
- Amy March as Dawn
- Elizabeth "Beth" March as Sabrina
- Theodore "Laurie" Laurence as Pikachu
- John Brooke as Brock
- Mr. Laurence as Turtwig
- Aunt March as Zoey
- Mr. March as Buizel
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