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In Memory

Smsunfl Timothy

Patient Information

Age: 16

Sex: Male

Diagnosed: 07/2/96

Location: Indiana, PA

Diagnosis: Originally diagnosed with stage IV carcinoma of unknown primary site. DSRCT Diagnosis confirmed at NIH. Also had Common Variable Hypogammaglobulinemia, a genetic primary immunodeficiency disease, and recieved IVIg for six years.

Hospital Children's Hospital of Pittsburgh

Oncologist Dr. Jeffrey Hord'.
Consultant Dr Brian Kushner

Passed Away: 04/30/97 one week after auto stem cell transplant, death occured from multiorgan failfure secondary to sepsis

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Treatment

Diagnosis: Multiple metastatic sites including: liver, spleen, pancreas, adrenals, a pelvic mass, cardinal nodes, mesenteric nodes, thoracic nodes, bone mets and, most unusually, bone marrow involvement.

Complication: Seven years of Common Variable Immuno-deficiency for which he received IVIgG.

Chemotherapy: Kushner's protocol: 7 chemo cycles = adriamycin, vincristine, and cytoxin cycled with ifosfamide and etoposide

Surgery Debulking: Removed omentum, biopsied his liver, and removed tumor seeding from the peritoneal wall and diaphragm. Unable to completely resect the tumor. The liver found to still contain a large amount of tumor.

Stem Cell

High dose: thiotepa and carboplatin, given over a period of six days.

Complications: Developed a severe infection with multi organ failure. Major cardiac and kidney complications.

Time Line

Date Test Treatment Chemicals Result
7/2/96 0 0 0 Misdiagnosed withstage IV carcinoma of unknown primary site
8/96 0 0 0 0
9/96 0 Chemotherapy 1 0 0
10/96 0 Chemotherapy - 2 P6 - adriamycin, vincristine, and cytoxin 0
10/96 0 Chemotherapy 3 P6 - adriamycin, vincristine, and cytoxin 0
11/96 0 Chemotherapy 4 P6 - adriamycin, vincristine, and cytoxin 0
12/96 0 Chemotherapy 5 P6 - adriamycin, vincristine, and cytoxin 0
1/97 0 Chemotherapy 6 P6 - ifosfamide and etoposide 0
2/97 0 Chemotherapy 7 P6 - ifosfamide and etoposide 0
3/97 0 Debulking surgery 0 Removed omentum, biopsied liver, and removed tumor seeding from the peritoneal wall and diaphragm. Unable to completely resect the tumor. The liver found to still contain a large amount of tumor.
4/14/97 0 Stem Cell - High dose chemo started thiotepa and carboplatin 0
4/23/97 0 Stem cell transplant started 0 0
4/30/97 0 0 0 Experienced multi-organ (cardiac and kidney) failure. Passed Away

10

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