- Arnold as Alvin
- Ralphie as Simon
- Carlos as Theodore
- Wanda as Britanny
- Keesha as Jeanette
- Dorothy Ann as Eleanor
- Arnold's Father as Dave Seville
- Ms. Frizzle as Miss Miller
- Arnold's Mother as Vinny/Claire Wilson
- Mr. Junkitt as Uncle Harry/Ian Hawke
- Murph as Miss Stone/Dr. Rubin
- Wanda's Grandma as Aunt Jackie Seville
- Wanda's Father as Toby Seville
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