- John W. Creasy as The Cat in the Hat
- Guadalupe "Lupita" Martin Ramos as Cindy Lou Who
- Lisa Martin Ramos as Sarah Hall-Small
- Samuel Ramos as Sam-I-Am
- Paul Rayburn as Mack the Turtle
- Miguel Manzano as King Derwin
- Mariana Garcia Guerrero as Pam-I-Am
- Victor Fuentes as Mr. Knox
- Jordan Kalfus as Fox in Socks
- Sister Anna as Joan
- Aurelio Sanchez as The Grinch
- Jorge Ramirez as Joey
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