- Charlie Ryan as Bart Simpson
- Joe Bastianich as Ned Flanders
- Graham Elliot as Barney Gumble
- Gordon Ramsay as Homer Simpson
- Kya Dawn Lau as Marge Simpson
- Logan Guleff as Grandpa Abe Simpson
- Troy Glass as Waylon Smithers, Jr.
- Ayla Destiny as Lisa Simpson
- Nathan Odom as Principal Seymour Skinner
- Josh Reisner as Moe Syzlak
- Samuel Stromberg as Dr. Julius Hibbert
- Oona Yaffe as Maude Flanders
- Jack Hoffman as Kent Brockman
- and more
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