- Matilda as Sarah Hall-Small
- Miss Honey as Daisy-Head Mayzie
- Miss Trunchbull as Jane Kangaroo
- Amanda Thripp as Cindy Lou Who
- Narrator as The Cat in the Hat
- Lavender as Pam-I-Am
- Charlie as Sam-I-Am
- Mrs. Thelps as Joan
- The FBI Agents as Mr. Knox & Fox in Socks
- Harry Wormwood as The Grinch
- Mike Wormwood as Norval the Fish
- Cookie as Aunt Myrtle
- Zinnia Wormwood as Izzy
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